Shinjiku Syndrome

Shinjiku Syndrome is a supposedly eradicated disease previously highly contagious and lethal disease. While the disease is mostly physical it has several frighting psychological effects on the person.

History

The disease is mostly known to inhabit in the Pacific regions of the world. It's been found to be quite common in sub-tropic and tropic climates. While the disease is usually unheard of today it isn't truly eradicated like some diseases may be. The virus still exists and can still be a potential infector. The disease was quite common in Kanami and Aqua Anu until the vaccine was developed.

Causes

The disease is caused by a pathological virus often at the point of sexual maturity in the body. It can occur earlier but this is the most common time for it to occur.

Replication for the virus is very rapid, while also demonstrating temporal control in replication. There are two genome segments. The first step involved is making mRNA copies of the - sense genome. This ensures that there is adequate proteins, which are required for replication. The N and L proteins are made from the mRNA produced. The - sense genome then makes vcRNA copies of itself which are + sense. The vcRNA is a template for producing - sense progeny but mRNA is also synthesized from it. The mRNA synthesized from vcRNA translate the G (spike) proteins and Z proteins. Thus, with this temporal control, the spike proteins are produced last, making the infection further undetected by the host immune system.

The Virus will infect just about every tissue in the human body. It starts with the mucosa, intestine, lungs and urinary systems, and then progresses to the vascular system and eventually.

Pathophysiology

The virus can be spread through airborne water droplets (Sneezing saliva etc) Other means of contact can occurs via exposure to animal excrement through the respiratory or gastrointestinal tracts. Inhalation of tiny particles of infective material (aerosol) is believed to be the most significant means of exposure. It is possible to acquire the infection through broken skin or mucous membranes that are directly exposed to infective material. Transmission from person to person has also been established, presenting a disease risk for health care workers. Frequency of transmission via sexual contact has not been established. Water contamination is also a factor of exposure.

Stages

The Disease has four stages to it.

Stage 1

After an incubation period of five to ten days, an acute illness with multiorgan involvement develops. Non-specific symptoms include fever, muscle fatigue, as well as conjunctivitis and mucosal bleeding.

Stage 2

More unusual symptoms begin to take place usually after the height of incubation. In females they begin to ejaculate menstrual fluid rapidly along with a high fever. Sometimes they give the appearance of being sexually aroused. In males it will usually be an erection lasting more than several hours again with a high fever. An acute sensitivity to phobias also show up such as photophobia (inability to tolerate bright light), phonophobia (inability to tolerate loud noises). Other already existing phobias may be enhanced to the level of having a sever and sudden Night Terrors especially when the inflicted tries to sleep. Irritability and delirium and seizures (in 20-40% of cases) swelling of the fontanelle (soft spot) may be present.

Stage 3

The Psychological effects take place. This is often considered the stage of insanity because most lose touch with reality at this point. Phobias are often enhanced with this stage and can often result in self inflicted physical damage.

Stage 4

The final stage may see a repeat of the same symptoms or sudden death. How a person dies is very subjective. Some die in their sleep others may die from sudden heart and respiratory failure.

Treatment

Up until 1908 the disease was widely untreatable. Doctors Amelliana Cortez, Koji Matsuda, Yasunori Mitsuda, and Allejandra Lopez developed a vaccine that could be administered to cure the disease if taken in the first stage. However because it's difficult to tell when one has a disease, it made it difficult to quickly administer the vaccine in time. However in 1912 Maricruze Lopez (The daughter of Allejandra Lopez) developed a vaccination that could be applied at birth or the reaching of sexual maturity.